Although the heart muscle maintains a base heart rate via myogenic stimulation, there are several circumstances that can cause an individual's heart rate to change, e.g.
Exercise
Stress
Relaxation
The brain is involved in the regulation of heart rate, though it does not require conscious thought
The branch of the nervous system that does not require conscious thought is known as the autonomic nervous system
The area of the brain that controls heart rate is the cardiovascular centre, located in a region of the brain called the medulla
The medulla is found at the base of the brain near the top of the spinal cord
Two nerves connect the medulla with the sinoatrial node (SAN):
One nerve connects to the acceleratory centre, which causes the heart to speed up
This happens in response to low blood pressure, low oxygen concentrations and low pH
These changes might occur during exercise
The blood vessels dilate, causing a decrease in blood pressure
The muscle cells are using up oxygen at a faster rate, causing blood oxygen levels to drop
The production of carbon dioxide by respiring cells causes blood pH to decrease
The other nerve connects to the inhibitory centre, which causes the heart to slow down
This happens in response to high blood pressure, high oxygen concentrations and high pH
These changes are likely to occur when the body is at rest
The heart rate is controlled by the cardiovascular centre in the medulla
Heart Rate: Alteration by Hormonal System
Epinephrine, also called adrenaline, is produced by the adrenal glands, located above the kidneys, in times of fear, stress, or excitement
The brain controls the release of epinephrine from the adrenal glands
Epinephrine increases the heart rate and boosts the delivery of oxygen and glucose to the brain and muscles, preparing the body for ‘flight or fight’
Increased glucose and oxygen are needed by the cells for aerobic respiration to release energy, e.g. to fuel the muscles to move/run away!