2018英特尔ISEF获奖作品摘要 生物医学工程 Intel Finalist Abstract Biomedical Engineering

获奖作品基本信息

年份	2018
学科	生物医学工程 Biomedical Engineering
国家/州	United States of America

获奖作品名称

A Novel Computational Solution to Advance Ferromagnetic NanoTherapy to Cure Cancer

获奖作品摘要

Cancer is a disease where mutated cells often clump together to form a tumor. Current oncological treatments include chemotherapy and radiotherapy, which often harm healthy tissue and have detrimental side-effects. Magnetic fluid hyperthermia is a promising cost-effective cancer treatment that uses magnetic nanoparticle (MNP) oscillations from an external alternating magnetic field to generate localized heating that destroys cancer cells with minimal effects on healthy tissue. However, this therapy lacks development due to its complex thermometry. To solve this problem, this interdisciplinary project proposes Ferromagnetic NanoTherapy, a novel computational solution that provides a powerful visualization tool to determine the required heat generation in a tumor for an optimized treatment. An interactive mathematical model was created on Python to calculate the magnetic thermal power based on the Neel and Brownian motion of the MNPs, magnetic field intensity, and MNP diameter and volumetric ratio. A 3D tumor Finite Element Analysis (FEA) model was created on ANSYS, where surrounding tissue and MNP injection site were defined with their respective thermophysical properties. A Computational Fluid Dynamics (CFD) model was developed to analyze the effects of blood perfusion on the MNP temperature distribution using Penne’s Bioheat Equation in ANSYS FLUENT. A small-scale prototype to generate the magnetic field was built with optimized parameters based on the mathematical model, and experimentation concurred with the FEA results. Overall, Ferromagnetic NanoTherapy allows the physician to determine the thermal dose required to advance magnetic fluid hyperthermia into routine clinical applications for a sustainable cancer treatment.

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ISEF 简介

英特尔国际科学与工程大奖赛，简称 "ISEF"，由美国 Society for Science and the Public（科学和公共服务协会）主办，英特尔公司冠名赞助，是全球规模最大、等级最高的中学生的科研科创赛事。ISEF 的学术活动学科包括了所有数学、自然科学、工程的全部领域和部分社会科学。ISEF 素有全球青少年科学学术活动的“世界杯”之美誉，旨在鼓励学生团队协作，开拓创新，长期专一深入地研究自己感兴趣的课题。

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英特尔 ISEF 学术活动详细介绍

英特尔 ISEF 全程指导方案

· 数学 · 物理 · 化学 · 生物 · 计算机 · 工程 ·

学科简介：生物医学工程 Biomedical Engineering

Projects that involve the application of engineering principles and design concepts to medicine and biology for healthcare purposes including diagnosis, monitoring and therapy.  Prominent biomedical engineering applications include the development of biocompatible prostheses, various diagnostic and therapeutic medical devices ranging from clinical equipment to micro-implants, common imaging equipment such as MRIs and EEGs, regenerative tissue growth, pharmaceutical drugs and therapeutic biologicals.

Subcategories:

Biomaterials and Regenerative Medicine (BMR): These studies involve the creation or use of biomaterials or biocompatible materials to construct a whole or a part of a living structure. These studies can include scaffolds for recruiting or supporting regenerative cells or tissues or the engineering designs for creating the correct environment for regenerative growth.

Biomechanics (BIE): Studies that apply classical mechanics (statics, dynamics, fluids, solids, thermodynamics, and continuum mechanics) to understand the function of biological tissues, organs, and systems and solve biological or medical problems. It includes the study of motion, material deformation, flow within the body and in devices, and transport of chemical constituents across biological and synthetic media and membranes.

Biomedical Devices (BDV): The study and/or construction of an apparatus that use electronics and other measurement techniques to diagnose, prevent and/or treat diseases or other conditions within or on the body.

Biomedical Imaging (IMG): The study and/or construction of an apparatus or technique that combines knowledge of a unique physical phenomenon (sound, radiation, magnetism, etc) with high speed electronic data processing, analysis and display to generate an image to support biomedical advances and procedures.

Cell and Tissue Engineering (CTE): Studies that utilize the anatomy, biochemistry and mechanics of cellular and sub-cellular structures in order to understand disease processes and to be able to intervene at very specific sites.

Synthetic Biology (SYN): Studies that involve the design and construction of new biological parts, devices and systems. Such studies include biological circuit design, genetic circuits, protein engineering, nucleic acid engineering, rational design, directed evolution and metabolic engineering.

OTH Other (OTH): Studies that cannot be assigned to one of the above subcategories. If the project involves multiple subcategories, the principal subcategory should be chosen instead of Other.