2019英特尔ISEF学科最佳作品摘要：转译医学 Best of Category Abstract: Translational Medical Science

获奖作品基本信息

年份	2019
学科	转译医学 Translational Medical Science
国家/州	FL，United States of America

获奖作品名称

Sharks Take a Bite Out of Infection! An Antibacterial, Reusable Bandage for Post-Operative Patients

获奖作品摘要

In the U.S., over 20 million cases of healthcare associated infections (HAIs) are reported, contributing to $3 trillion in healthcare costs and 5.9 million tons of waste annually. HAIs are currently treated with antibiotics, however antibiotic-resistant superbugs are increasing. Marine micro-fouling on wet surfaces is analogous to the proliferation of bacteria responsible for HAIs. This study had two goals: to assess marine micro-fouling on shark skin; and develop reusable, antibacterial bandages with shark skin-inspired surfaces. This study is first to quantify fouling on Blacktip shark skin (Carcharhinus limbatus) along dorsal and ventral surfaces, and mimics Bonnethead dermal denticles (Sphyrna tiburo) to create bandages. Shark skin (C. limbatus) and control petri dishes were assessed for fouling using NIH ImageJ. Samples were exposed to seawater and sunlight for 120 hours, where <3% of the skin and >98% of the control fouled. There was a positive correlation between presence of the microstructure (Engineered Roughness Index (ERI) = 15.313 μm) and inhibited bacteria growth. Shark skin denticles (S. tiburo) were Micro-CT scanned, CAD modeled, inverted, and 3D resin printed to create negative molds of shark skin with five different roughness factors (ERI between 1.972 and 16.026 μm). Bandages were created using PDMSe elastomer and assessed for growth from multiple strains of Staphylococcus, an isolate in 70% of HAIs. Bandages with similar morphology and roughness to shark skin were significantly more effective at blocking Staphylococcus adhesion and migration compared to a commercial bandage and PDMSe control. This bandage will reduce HAIs, healthcare costs, and waste.

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高中生科研学术活动 英特尔 Intel ISEF 简介

英特尔国际科学与工程大奖赛，简称 "ISEF"，由美国 Society for Science and the Public（科学和公共服务协会）主办，英特尔公司冠名赞助，是全球规模最大、等级最高的中学生的科研科创赛事。ISEF 的学术活动学科包括了所有数学、自然科学、工程的全部领域和部分社会科学。ISEF 素有全球青少年科学学术活动的“世界杯”之美誉，旨在鼓励学生团队协作，开拓创新，长期专一深入地研究自己感兴趣的课题。

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英特尔 ISEF 学术活动详细介绍

英特尔 ISEF 全程指导方案

· 数学 · 物理 · 化学 · 生物 · 计算机 · 工程 ·

学科简介：转译医学 Translational Medical Science

Projects that aim to improve human health and longevity by translating novel discoveries in the biomedical sciences into effective activities and tools for clinical and public health use. Bi-directional in concept, projects can be those developed through basic research moving toward clinical testing (bench-to-bedside) or projects that provide feedback about the applications of new treatments and how they can be improved (beside-to-bench).

Subcategories:

Disease Detection and Diagnosis (DIS): Studies in this category encompass a variety of novel assay methods to promote the identification, detection and determination of disorders and disease. They may involve studies at the system, organ, or cellular levels.

Disease Prevention (PRE): The study of health promotion and disease prevention activities and research to improve public health. These  studies might involve research to protect individuals from actual or potential health threats and their harmful consequences, or they may address novel approaches to aid in compliance for avoiding known health risks (e.g., smoking, drug use, obesity).

Disease Treatment and Therapies (TRE): The use of pharmaceuticals and other therapies, including natural and holistic remedies, intended to improve symptoms and treat or cure disorders or disease.

Drug Identification and Testing (DRU): These studies would be conducted to identify potential drugs or extracts that could be used to treat or cure disorders or disease. Studies in this category would involve initial testing of the compounds against an intended target. This category could also include testing a range of different compounds or extracts to determine relative potency and efficacy.

Pre-Clinical Studies (PCS): These studies of potential drugs or therapies would include testing the intervention in platforms such as cultured cells or animal models of disease. The investigations could be directed toward determining factors such as potential drug permeability, efficacy and/or toxicity. These studies could also investigate the best route of drug administration.

Other (OTH): Studies that cannot be assigned to one of the above subcategories. If the project involves multiple subcategories, the principal subcategory should be chosen instead of Other.