2018英特尔ISEF学科最佳作品摘要：转译医学 Best of Category Abstract: Translational Medical Science

获奖作品基本信息

年份	2018
学科	转译医学 Translational Medical Science
学校	Cherry Creek High School
国家/州	CO，United States of America

获奖作品名称

Bruxism: A Novel Diagnostic Approach

获奖作品摘要

Bruxism, the involuntary grinding and/or clenching of teeth, is a condition which often goes undiagnosed until irreversible damage occurs. Although research on this topic has been extensive, there is still no objective diagnostic method for bruxism. Current diagnostic methods, based on clinical examination and patient history, are frequently inaccurate. Previous research has identified masticatory muscles as the main generators of human bite force. With the aid of an original device (a novel bite force recorder) which I designed, this study aimed to explore the existence of a correlation between individuals’ maximum bite force (MBF) values and bruxism. My results showed that MBF values recorded for bruxers (experimental group) were significantly higher than those for non-bruxers (control). Since occlusal guards help masticatory muscles relax and lose their hyperactive status, splint therapy is the standard procedure for treating bruxism. After four weeks of splint therapy, the MBF values recorded for bruxers displayed a significant decrease, while there was no statistically significant change for non-bruxers. These findings support my hypothesis that increased MBF values could be an indication of bruxism and could provide useful data for evaluation of jaw muscle function and activity. Measuring individuals’ MBF values could be instrumental in diagnosing bruxism. With bruxism being on the rise, additional research is required to further develop more efficient and more cost-effective methods to diagnose this condition.

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高中生科研学术活动 英特尔 Intel ISEF 简介

英特尔国际科学与工程大奖赛，简称 "ISEF"，由美国 Society for Science and the Public（科学和公共服务协会）主办，英特尔公司冠名赞助，是全球规模最大、等级最高的中学生的科研科创赛事。ISEF 的学术活动学科包括了所有数学、自然科学、工程的全部领域和部分社会科学。ISEF 素有全球青少年科学学术活动的“世界杯”之美誉，旨在鼓励学生团队协作，开拓创新，长期专一深入地研究自己感兴趣的课题。

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英特尔 ISEF 学术活动详细介绍

英特尔 ISEF 全程指导方案

· 数学 · 物理 · 化学 · 生物 · 计算机 · 工程 ·

学科简介：转译医学 Translational Medical Science

Projects that aim to improve human health and longevity by translating novel discoveries in the biomedical sciences into effective activities and tools for clinical and public health use. Bi-directional in concept, projects can be those developed through basic research moving toward clinical testing (bench-to-bedside) or projects that provide feedback about the applications of new treatments and how they can be improved (beside-to-bench).

Subcategories:

Disease Detection and Diagnosis (DIS): Studies in this category encompass a variety of novel assay methods to promote the identification, detection and determination of disorders and disease. They may involve studies at the system, organ, or cellular levels.

Disease Prevention (PRE): The study of health promotion and disease prevention activities and research to improve public health. These  studies might involve research to protect individuals from actual or potential health threats and their harmful consequences, or they may address novel approaches to aid in compliance for avoiding known health risks (e.g., smoking, drug use, obesity).

Disease Treatment and Therapies (TRE): The use of pharmaceuticals and other therapies, including natural and holistic remedies, intended to improve symptoms and treat or cure disorders or disease.

Drug Identification and Testing (DRU): These studies would be conducted to identify potential drugs or extracts that could be used to treat or cure disorders or disease. Studies in this category would involve initial testing of the compounds against an intended target. This category could also include testing a range of different compounds or extracts to determine relative potency and efficacy.

Pre-Clinical Studies (PCS): These studies of potential drugs or therapies would include testing the intervention in platforms such as cultured cells or animal models of disease. The investigations could be directed toward determining factors such as potential drug permeability, efficacy and/or toxicity. These studies could also investigate the best route of drug administration.

Other (OTH): Studies that cannot be assigned to one of the above subcategories. If the project involves multiple subcategories, the principal subcategory should be chosen instead of Other.