2018英特尔ISEF学科最佳作品摘要：生物医学与健康科学 | Best of Category Abstract: BIOMEDICAL AND HEALTH SCIENCES

获奖作品基本信息

年份	2018
学科	生物医学与健康科学 BIOMEDICAL AND HEALTH SCIENCES
学校	University School of Milwaukee
国家/州	WI，United States of America

获奖作品名称

Role of Telomerase in Vascular Function and Exploration of Mitochondrial Dynamics: A Novel Approach to Treatment of Vascular Dysfunction

获奖作品摘要

Coronary Artery Disease (CAD), an aging related detriment, is the most common cause of mortality in the world. In addition, chemotherapy jeopardizes cardiovascular integrity and was shown to be interconnected with CAD via RNAseq. Telomerase, an anti-aging related enzyme, is a nuclear derived telomere regulator and was hypothesized to mitigate the vascular effects of aforementioned ailments. Following creation of a specialized videomicrocopy apparatus, global activation of telomerase resulted in restored vascular function amidst CAD and chemotherapy. Separate from its conventional nuclear role, telomerase was shown to translocate to the mitochondria and preserve mitochondrial function. As global overexpression of telomerase is known to be oncogenic, a novel, clinically applicable mitochondrial telomerase decoy peptide was created in order to preserve therapeutic effects with minimal oncogenic activity. The decoy peptide restored vascular function and preserved cellular integrity amidst CAD, chemotherapy and vascular stressors. In order to accelerate telomerase-related drug development, a unique computational method using a developed at-home computational cluster was developed. Moreover, an ultra precise mechanistic mathematical model of the mitochondrial dynamics was created in order to simulate and predict novel mitochondrial telomerase interactions as well as further explore mitochondrial systems. This multidisciplinary study presents a revolutionary mechanism to combat CAD and preserve vascular function amidst chemotherapy. Additionally, the developed platform technologies have implications with many other diseases, representing a promising advancement to the biomedical field.

 

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ISEF 简介

英特尔国际科学与工程大奖赛，简称 "ISEF"，由美国 Society for Science and the Public（科学和公共服务协会）主办，英特尔公司冠名赞助，是全球规模最大、等级最高的中学生的科研科创赛事。ISEF 的学术活动学科包括了所有数学、自然科学、工程的全部领域和部分社会科学。ISEF 素有全球青少年科学学术活动的“世界杯”之美誉，旨在鼓励学生团队协作，开拓创新，长期专一深入地研究自己感兴趣的课题。

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英特尔 ISEF 学术活动详细介绍

英特尔 ISEF 全程指导方案

· 数学 · 物理 · 化学 · 生物 · 计算机 · 工程 ·

学科简介：生物医学与健康科学 BIOMEDICAL AND HEALTH SCIENCES

This category focuses on studies specifically designed to address issues of human health and disease. It includes studies on the diagnosis, treatment, prevention or epidemiology of disease and other damage to the human body or mental systems. Includes studies of normal functioning and may investigate internal as well as external factors such as feedback mechanisms, stress or environmental impact on human health and disease.

Subcategories:

Cell, Organ, and Systems Physiology (PHY): These studies investigate mechanisms that are involved in maintaining health or when disrupted, cause disease. They could involve investigating such things as the role of cell signaling pathways both within the cell (intracellular) and/or between cells (extracellular). Alternatively, studies in this subcategory could investigate the maintenance of homeostasis at the organ or whole body level (e.g., hormonal control and regulation). These studies may also be in areas such as disease-related, stress-related, biochemical, mechanical, or physical changes at the tissue, organ, and /or cellular level.

Genetics and Molecular Biology of Disease (GEN): These studies investigate the genetic and molecular mechanisms involved in the regulatory pathways that maintain normal body and cellular function or if disturbed can lead to disease. Studies could include examining the activation and deactivation of genes (e.g., transcription factors or epigenetic regulation) or involve more classical genetic identification studies.

Immunology (IMM): These studies will investigate any aspects of the immune system that are involved in maintaining health or when altered lead to pathology. These studies can include new investigations of normal immune function (e.g., immune cell interactions and signaling), or they may study diseases caused by disorders in regulation of the immune system (e.g., immunodeficiency or autoimmunity). Alternatively the studies could investigate problems such as graft vs host or host versus graft disease that arise during the treatment of other diseases or conditions.

Nutrition and Natural Products (NTR): The study of food, nutrients and dietary need in humans, and the effects of food and nourishment on the body.  These studies may include the effects of natural or supplemental nutrients and nutrition.

Pathophysiology (PAT): These studies will be focused on determining specific causes of disease and on physiological mechanisms responsible for disease development. Investigations in this category will examine changes in the normal physiological balance, or homeostasis that cause a reaction(s) within the body leading to disease.

Other (OTH): Studies that cannot be assigned to one of the above subcategories. If the project involves multiple subcategories, the principal subcategory should be chosen instead of Other.